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In addition, ursodeoxycholic acid produced by Lactobacillus acidophilus inhibits proinflammatory macrophage polarization by upregulating RapGAP ( Akkermansia muciniphila enhances retinoic acid synthesis in dendritic cells, thereby inducing type 3 innate lymphoid cells (ILC3s) to secrete IL-22, a cytokine critical for mucosal repair (Liu H

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Additionally, the lack of long-term studies leaves questions about sustained benefits and potential tolerance unresolved